Journal of Pathology and Translational Medicine

Jong Seok Lee

3 Articles

Chondroblastoma of the Lumbar Spine: A Case Report and Review of the Literature.: Sun A Kim, Kyung Ja Cho, Yong Koo Park, Jong Seok Lee, Heon Ju Kwon, Hyewon Chung, Mi Jung Kim; Korean J Pathol. 2011;45(5):532-536.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.5.532

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We report a case of chondroblastoma arising in the lumbar spine in a 25-year-old man who presented with low back pain of 5 years duration. Plain radiography and computed tomography revealed a well-defined osteolytic mass surrounded by marginal sclerosis in the third lumbar vertebra. The mass encroached on the left neural foramen on magnetic resonance imaging. Histologically, the tumor consisted of round to oval cells with eosinophilic cytoplasm and randomly scattered osteoclastic type giant cells. There were characteristic chicken-wire calcification and aneurysmal bone cyst-like changes. Chondroblastomas of the lumbar spine are extremely rare, and only nine cases have been reported. Spinal chondroblastoma should be distinguished from other benign bone tumors, because it tends to show aggressive biological behavior with high recurrence and mortality rates.

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Chondroblastoma of Thoracic Vertebrae: a Case Report and Review of the Literature
Alireza Tabibkhooei, Parisa Javadnia
Indian Journal of Surgical Oncology.2024; 15(S1): 22. CrossRef
Clinicopathological characteristics and prognostic factors in axial chondroblastomas: a retrospective analysis of 61 cases and comparison with extra-axial chondroblastomas
Bo-Wen Zheng, Bo-Yv Zheng, Hua-Qing Niu, Ming-Xiang Zou, Hai-Lin Wu, Ming Wang, Xue-Lin Li
World Journal of Surgical Oncology.2023;[Epub] CrossRef
Commentary on Letter to the Editor concerning “Management of cranial chondroblastoma in adults; a pooled analysis” by Amr Muhammed et al.
Amr Muhammed
American Journal of Otolaryngology.2021; 42(1): 102749. CrossRef
Prognostic Significance of Tumor-Associated Macrophages in Chondroblastoma and Their Association with Response to Adjuvant Radiotherapy
Bo-Wen Zheng, Min-Liang Yang, Wei Huang, Bo-Yv Zheng, Tao-Lan Zhang, Jing Li, Guo-Hua Lv, Yi-Guo Yan, Ming-Xiang Zou
Journal of Inflammation Research.2021; Volume 14: 1991. CrossRef
Sacral chondroblastoma — a rare location, a rare pathology: A case report and review of literature
Bo-Wen Zheng, Hua-Qing Niu, Xiao-Bin Wang, Jing Li
World Journal of Clinical Cases.2021; 9(20): 5709. CrossRef
Intraoperative crush smear cytology of vertebral chondroblastoma: A diagnostic challenge
Shilpa P. Tathe, Sanjay N. Parate, Kirti N. Jaiswal, Archana A. Randale
Diagnostic Cytopathology.2018; 46(1): 79. CrossRef
Clinical features, treatments and long-term follow-up outcomes of spinal chondroblastoma: report of 13 clinical cases in a single center
Qi Jia, Chao Liu, Jian Yang, Yong Ji, Haifeng Wei, Tielong Liu, Xinghai Yang, Cheng Yang, Jianru Xiao
Journal of Neuro-Oncology.2018; 140(1): 99. CrossRef
Chondroblastoma of the thoracic spine: a rare location. Case report with radiologic-pathologic correlation
A. Venkatasamy, M. P. Chenard, G. Massard, J.-P. Steib, G. Bierry
Skeletal Radiology.2017; 46(3): 367. CrossRef

The Expressions of E2F1 and p53 in Gastrointestinal Stromal Tumors and Their Prognostic Significance.: Mi Jung Kwon, Eun Sook Nam, Seong Jin Cho, Hye Rim Park, Hyung Sik Shin, Jong Seok Lee, Chan Heun Park, Woon Geon Shin; Korean J Pathol. 2009;43(3):212-220.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.3.212

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Abstract PDF

BACKGROUND
E2F1 plays a critical role in the G1-to-S phase transition by inducing various genes that encode S phase-activating proteins and that modulate such diverse cellular functions as DNA synthesis, mitosis and apoptosis. The purpose of this study was to assess the E2F1 expression in relation to the clinicopathologic parameters and other tumor markers in gastrointestinal stromal tumors.
METHODS
Immunohistochemical stainings for obtaining the E2F1, p53, and Ki-67 labeling indices were performed on a tissue microarray of 72 gastrointestinal stromal tumor specimens. The clinicopathologic parameters that were analyzed including the risk grade system by Miettinen et al. and the disease-free survival (DFS) rate.
RESULTS
1) An E2F1 expression was correlated with a larger tumor size, a p53 expression and a shorter period of DFS (p=0.014, p=0.007, and p=0.039). 2) A p53 expression was significantly associated with a high risk grade, a larger tumor size, high mitotic counts and a shorter period of DFS (p=0.003, p=0.044, p<0.001, and p<0.0001). 3) A high-risk grade and the epithelioid type were significantly associated with a shorter period of DFS (p=0.0006 and p=0.0008).
CONCLUSIONS
E2F1, as well as p53, may be a potentially novel independent prognostic factor for predicting a worse outcome for those patients suffering with Gastrointestinal stromal tumors.

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Comparison of tissue microarray and full section in immunohistochemistry of gastrointestinal stromal tumors
Mi Jung Kwon, Eun Sook Nam, Seong Jin Cho, Hye Rim Park, Hyung Sik Shin, Jun Ho Park, Chan Heun Park, Won Jae Lee
Pathology International.2009; 59(12): 851. CrossRef

Angiomatoid Fibrous Histiocytoma: A Case Report.: Kyungeun Kim, Jong Seok Lee, Kyung Ja Cho; Korean J Pathol. 2006;40(5):377-380.

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Abstract PDF: We report on a case of angiomatoid fibrous histiocytoma located deep in subcutaneous tissue of the left shoulder in an 11-year-old boy. An ovoid firm mass was slowly increasing in size for 5 months without any pain or tenderness. The tumor was grossly multicystic, with dense fibrous capsule and it measured 7.5 x 7.5 x 4.0 cm. The locules contained hemorrhagic fluid, and the inner surface was purplish brown and trabecular. The septal solid areas were cellular, and they consisted of histiocytoid spindle cells that were arranged in a storiform or fascicular pattern. The tumor cells showed immuno-positivity for CD99, CD68 and desmin. These findings were compatible with angiomatoid fibrous histiocytoma of an uncommon location.

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